Look what second hand smoking does to humans. Snakes now basicly have only one full working lung, and their well being depends on their enviroment. If its in the same room it does have direct contact with it, unless its enclosure is air tight, and because its in an enclosure anything that gets in there will take longer to get out. It does affect them, and with one main lung it affects them much more then it would humans or dogs and cats. Definatly smoke in a different room.