I did this back in January or February 2014, forget when, but the drive was from Albuquerque, NM to Little Elm, TX. I think it took us 11 or 12 hours.
I went to Lowes and bought 1 inch Styrofoam board and multiple 18x18x16 boxes. I cut the foam to fit as if I were lining the box for shipping. All sub-adult and adult snakes went into pillow cases, all hatchling and yearling/juvie snakes went into deli cups, and lizards (some 50-60 geckos, 1 beardie, and 2 ackies) went into deli cups, and I loaded the crap out of the boxes. All were moved within vehicle cabs (I was in 10ft budget truck and my wife was in her 2013 ford focus (damn thing can hold a lot!)).
I forget how many scale-babies we moved, but it was pushing 100. We also moved 2 cats, which thankfully both were either sleeping or wanting to be pet vs needing to use restroom. Sadly, when we moved this spring a whole 45 minutes away, our male cat decided to blow up #1 and 2 within his carrier. 10 hours...perfectly fine, 45 minutes...NOPE!