Hi Newbie!
I let my snakes know I'm there by offering them the back of my hand (like you do to a dog you don't know) and then I pick them up. Snakes are more comfortable if you support their body in more than one spot, so don't just grab the tail ot the middle....and most deffinately not the head!! Depending on the ae of your anke, when you got it and it's individual personality, it could be very relaxed from the beginning, never really like being handled, or it will warm up to you at it's own pace.