Some snakes are just inherently more calm than others, but if you notice it's getting stressed, or stops eating, then you might want to ease off. Otherwise, I wouldn't worry about handling it a few times during the day. Little babies can get a little more jumpy, just because they're so small, so judge by the behavior how it's doing. Make sure you don't handle for at least two days after feeding though, if you don't already do that.